FORT MYERS, Florida — Clay Buchholz pitched two hitless innings, David Ortiz homered and the Boston Red Sox beat the Minnesota Twins 10-2 on Monday night.

Buchholz, who missed much of last season with a stress fracture in his back, struck out two and walked two.

Jason Marquis struggled in his debut for Minnesota, allowing four runs in 1 2-3 innings.

Boston scored four times in the second and led 5-0 after three. Backup catcher Daniel Butler added a three-run homer in the seventh inning.

Joe Mauer went 2 for 3 with an RBI for Minnesota.